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pentobarbital will minimize the level or impact of alosetron by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown.pentobarbital will increase toxicity of ifosfamide by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep track of. CYP3A4 inducers might raise the metabolism of ifosfamide to its